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My lab’s overarching hypothesis is that the adaptive immune system plays a fundamental role in functional plasticity and subsequent motor and cognitive recovery within the injured brain. Preclinical studies investigate mechanisms by which adaptive immune responses affect post-stroke plasticity, while concomitantly confirming and characterizing these cells in patients. Clinical studies focus on the role of neuroinflammation during brain injury and repair and have expanded beyond the field of ischemic stroke to include subjects with or at-risk for dementia, as well as pediatric patients on ventilator and hemodynamic support who experience stroke. The combination of preclinical and clinical studies reflects both my own training, which included a clinical postdoctoral fellowship, and my ongoing scientific philosophy that translational research will hasten our understanding of functional recovery during and following brain injury.